STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC
نویسندگان
چکیده
منابع مشابه
STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC
BACKGROUND Whole-cell tumor vaccines have shown much promise; however, only limited success has been achieved for the goal of eliciting robust tumor-specific T-cell responses. METHODS Hepatocellular carcinoma (HCC) cells, H22 and Hepa1-6, were modified by blocking the STAT3 signaling pathway with a STAT3 decoy oligodeoxynucleotide, and the immunogenicity and possibility of using these cell ly...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2017
ISSN: 1756-9966
DOI: 10.1186/s13046-017-0623-0